In this episode of the a16z podcast, hosts Sima Amble and Fabrizio Serafini are joined by Ari Weinstein and James Sun from OpenAI to discuss the rapid evolution, current state, and future of computer using agents.
The discussion highlights the launch of Astra, OpenAI's newest model, which marks a significant leap in computer use capabilities. While previous models were already competent, Astra brings key enhancements: it is faster, uses fewer thinking tokens, performs better on creative tasks (such as drawing in Microsoft Paint), and boasts higher reliability around the edges, moving closer to 99% reliability. Furthermore, Astra is OpenAI’s most aligned model, featuring strong resistance to prompt injection and unintended actions, which builds vital trust for enterprise deployments. Beyond practical work, Astra is exceptionally proficient at playing video games, beating previous models and even playing games like Fallout for hours.
The conversation explores the different implications and use cases for consumers and enterprises. For consumers, computer-using agents act as personal helpers in daily life—such as DOTS, a tool that gets its own cloud computer and web browser to handle tedious tasks like booking appointments, flagging unconfirmed calendar invites in Gmail, and proactively managing Slack messages and Sentry logs. For enterprises, computer use acts as a universal API to navigate legacy software that lacks modern MCP tools or APIs. Businesses can automate tedious workflows across systems of record like ERPs, CRMs, and finance ledgers (such as procurement, expense reconciliation, and market research).
To ensure safety and build enterprise trust, OpenAI has introduced determinative controls, sandboxing capabilities, and human-in-the-loop options like auto-approve modes via the app's "guardian" system. These tools allow administrators to set strict boundaries on what websites or apps an agent can access and mandate human approval for sensitive actions like downloads, uploads, or visiting new sites.
Addressing how agents interact with application software and the open web, the speakers discuss the tension with web publishers whose revenue depends on human ad impressions, as well as the adoption of standards like WebMCP that allow humans and agents to collaborate smoothly on websites.
Looking forward, OpenAI is heavily focused on increasing model speed. The speakers note that computer-using agents are already faster than the average human at using a computer, and they are rapidly approaching "superhuman" speed where they outperform expert computer users. This shift will fundamentally change how people interact with computers. While background execution remains a major strength, real-time collaboration and voice-driven computer use will become increasingly prominent.
Finally, the speakers emphasize the enduring value of software craftsmanship and user interfaces. Even as cheap software and autonomous agents proliferate, human intuition, direct manipulation, and purpose-built UI will remain essential for both consumer joy and enterprise auditability. Startups still have massive opportunities by combining deep industry expertise, go-to-market execution, and vertical software workflows that bridge disparate systems together. Ultimately, the industry is entering a major scaling moment for computer-using agents, bridging the gap between powerful background automation and coherent, human-centered experiences.